June, Carl H. Litigation, Intellectual Property, Attorneys, SEC Filings, and Other Public Records

Date Recorded	Party	Role	Document Type	Document No.	Invention Title

7/27/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Publication	18477584 US2024001827	Enhancing Activity of CAR T Cells by Co-Introducing a Bispecific Antibod... Enhancing Activity of CAR T Cells by Co-Introducing a Bispecific Antibod...

7/17/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Application	PCT/US2025/0 19607161	Compositions And Methods Comprising 3 Prime Utr Stem Loop Mediated Trans... Compositions And Methods Comprising 3' Utr Stem Loop Mediated Transgene ...

7/17/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Application	19607161 PCT/US2025/0	Compositions And Methods Comprising 3' Utr Stem Loop Mediated Transgene ... Compositions And Methods Comprising 3 Prime Utr Stem Loop Mediated Trans...

6/2/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Publication	17937488 20230052970	Phosphoglycerate Kinase 1 (pgk) Promoters And Methods Of Use For Express... Phosphoglycerate Kinase 1 (pgk) Promoters And Methods Of Use For Express...

6/2/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Publication	17937488 20230052970	Phosphoglycerate Kinase 1 (pgk) Promoters And Methods Of Use For Express... Phosphoglycerate Kinase 1 (pgk) Promoters And Methods Of Use For Express...

6/2/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Publication	17937488 20230052970	Phosphoglycerate Kinase 1 (pgk) Promoters And Methods Of Use For Express... Phosphoglycerate Kinase 1 (pgk) Promoters And Methods Of Use For Express...

6/2/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Publication	17937488 20230052970	Phosphoglycerate Kinase 1 (pgk) Promoters And Methods Of Use For Express... Phosphoglycerate Kinase 1 (pgk) Promoters And Methods Of Use For Express...

4/27/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Publication	PCT/US2019/0 62624707 16965880 20210038659	Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor

4/27/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Publication	PCT/US2019/0 62624707 16965880 20210038659	Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor

4/27/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Publication	PCT/US2019/0 62624707 16965880 20210038659	Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor

4/27/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Publication	62624707 16965880 PCT/US2019/0 20210038659	Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor

4/27/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Publication	16965880 PCT/US2019/0 62624707 20210038659	Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor

4/27/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Publication	16965880 PCT/US2019/0 62624707 20210038659	Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor

4/27/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Publication	16965880 PCT/US2019/0 62624707 20210038659	Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor

4/27/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Publication	62624707 16965880 PCT/US2019/0 20210038659	Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor

4/27/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Publication	16965880 PCT/US2019/0 62624707 20210038659	Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor

4/27/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Publication	62624707 16965880 PCT/US2019/0 20210038659	Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor

4/27/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Publication	16965880 PCT/US2019/0 62624707 20210038659	Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor

4/27/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Publication	16965880 PCT/US2019/0 62624707 20210038659	Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor

4/27/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Publication	16965880 PCT/US2019/0 62624707 20210038659	Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor

4/27/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Publication Patent	16965880 62624707 PCT/US2019/0 20210038659 12653850	Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor Combination Therapy Using A Chimeric Antigen Receptor

3/31/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Publication	17370655 20210338733	Tn-muc1 Chimeric Antigen Receptor (car) T Cell Therapy Tn-muc1 Chimeric Antigen Receptor (car) T Cell Therapy

3/31/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Publication	17370655 20210338733	Tn-muc1 Chimeric Antigen Receptor (car) T Cell Therapy Tn-muc1 Chimeric Antigen Receptor (car) T Cell Therapy

3/31/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Publication	17370655 20210338733	Tn-muc1 Chimeric Antigen Receptor (car) T Cell Therapy Tn-muc1 Chimeric Antigen Receptor (car) T Cell Therapy

3/31/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Publication	17370655 20210338733	Tn-muc1 Chimeric Antigen Receptor (car) T Cell Therapy Tn-muc1 Chimeric Antigen Receptor (car) T Cell Therapy

3/31/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Publication	17370655 20210338733	Tn-muc1 Chimeric Antigen Receptor (car) T Cell Therapy Tn-muc1 Chimeric Antigen Receptor (car) T Cell Therapy

3/31/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Publication	17370655 20210338733	Tn-muc1 Chimeric Antigen Receptor (car) T Cell Therapy Tn-muc1 Chimeric Antigen Receptor (car) T Cell Therapy

3/31/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Publication	17370655 20210338733	Tn-muc1 Chimeric Antigen Receptor (car) T Cell Therapy Tn-muc1 Chimeric Antigen Receptor (car) T Cell Therapy

3/31/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Publication Patent	17370655 20210338733 12624081	Tn-muc1 Chimeric Antigen Receptor (car) T Cell Therapy Tn-muc1 Chimeric Antigen Receptor (car) T Cell Therapy Tn-MUC1 Chimeric Antigen Receptor (CAR) T Cell Therapy

3/19/2026	The Trustees Of The University Of Pennsy...	Assignee	Application	19167298	Compositions And Methods For Genome Editing

3/19/2026	The Trustees Of The University Of Pennsy...	Assignee	Application	19167298	Compositions And Methods For Genome Editing

3/19/2026	The Trustees Of The University Of Pennsy...	Assignee	Application	19167298	Compositions And Methods For Genome Editing

3/19/2026	The Trustees Of The University Of Pennsy...	Assignee	Application	19167298	Compositions And Methods For Genome Editing

2/11/2026	The Trustees Of The University Of Pennsy...	Assignee	Application	19453906	TREATMENT OF CANCER USING HUMANIZED ANTI-EGFRvIII CHIMERIC ANTIGEN RECEP...

2/11/2026	The Trustees Of The University Of Pennsy...	Assignee	Application	19453906	TREATMENT OF CANCER USING HUMANIZED ANTI-EGFRvIII CHIMERIC ANTIGEN RECEP...

1/7/2026	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Application Publication Publication Publication Publication Patent Patent Patent Patent	17550455 15516052 17456436 15962379 20220154190 20170290858 20220145306 20180312848 12570982 11208661 12577567 11203758	Altering Gene Expression in Modified T Cells and Uses Thereof Altering Gene Expression in Modified T Cells and Uses Thereof Altering Gene Expression in Modified T Cells and Uses Thereof Altering Gene Expression in Modified T Cells and Uses Thereof Altering Gene Expression in Modified T Cells and Uses Thereof Altering Gene Expression in Modified T Cells and Uses Thereof Altering Gene Expression in Modified T Cells and Uses Thereof Altering Gene Expression in Modified T Cells and Uses Thereof Altering Gene Expression in Modified T Cells and Uses Thereof Altering Gene Expression in Modified T Cells and Uses Thereof Altering Gene Expression in Modified T Cells and Uses Thereof Altering Gene Expression in Modified T Cells and Uses Thereof

12/10/2025	The Trustees Of The University Of Pennsy...	Assignee	Application Publication	17677208 20230013642	Toxicity Management for Anti-Tumor Activity of CARs Toxicity Management for Anti-Tumor Activity of CARs

12/10/2025	The Trustees Of The University Of Pennsy...	Assignee	Application Publication	17677208 20230013642	Toxicity Management for Anti-Tumor Activity of CARs Toxicity Management for Anti-Tumor Activity of CARs

12/10/2025	The Trustees Of The University Of Pennsy...	Assignee	Application Publication	17677208 20230013642	Toxicity Management for Anti-Tumor Activity of CARs Toxicity Management for Anti-Tumor Activity of CARs

12/10/2025	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Application Publication	18937759 19233446 19413358 17677208 20230013642	Toxicity Management for Anti-Tumor Activity of CARs Toxicity Management For Anti-tumor Activity Of Cars Toxicity Management for Anti-Tumor Activity of CARs Toxicity Management for Anti-Tumor Activity of CARs Toxicity Management For Anti-tumor Activity Of Cars

12/10/2025	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Application Publication	19413358 17677208 18937759 19233446 20230013642	Toxicity Management for Anti-Tumor Activity of CARs Toxicity Management for Anti-Tumor Activity of CARs Toxicity Management For Anti-tumor Activity Of Cars Toxicity Management for Anti-Tumor Activity of CARs Toxicity Management For Anti-tumor Activity Of Cars

12/10/2025	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Application Publication	19413358 17677208 18937759 19233446 20230013642	Toxicity Management for Anti-Tumor Activity of CARs Toxicity Management For Anti-tumor Activity Of Cars Toxicity Management for Anti-Tumor Activity of CARs Toxicity Management For Anti-tumor Activity Of Cars Toxicity Management for Anti-Tumor Activity of CARs

12/10/2025	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Application Publication	18937759 19233446 19413358 17677208 20230013642	Toxicity Management for Anti-Tumor Activity of CARs Toxicity Management For Anti-tumor Activity Of Cars Toxicity Management for Anti-Tumor Activity of CARs Toxicity Management for Anti-Tumor Activity of CARs Toxicity Management For Anti-tumor Activity Of Cars

5/30/2025	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Application Publication Publication Publication Patent Patent Patent	17318316 16014133 16014804 17029487 20220056116 20190085063 20180371068 12350334 11299536 10800840	Compositions and Methods for Generating a Persisting Population of T Cel... Compositions and Methods for Generating a Persisting Population of T Cel... Compositions and Methods for Generating a Persisting Population of T Cel... Compositions and Methods for Generating a Persisting Population of T Cel... Compositions and Methods for Generating a Persisting Population of T Cel... Compositions and Methods for Generating a Persisting Population of T Cel... Compositions and Methods for Generating a Persisting Population of T Cel... Compositions and Methods for Generating a Persisting Population of T Cel... Compositions and Methods for Generating a Persisting Population of T Cel... Compositions and Methods for Generating a Persisting Population of T Cel...

5/1/2025	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Publication Publication Publication	15516240 18468043 16943335 20240279665 20200407728 20170335331	Altering Gene Expression in CART Cells and Uses Thereof Altering Gene Expression in CART Cells and Uses Thereof Altering Gene Expression in CART Cells and Uses Thereof Altering Gene Expression in CART Cells and Uses Thereof Altering Gene Expression in CART Cells and Uses Thereof Altering Gene Expression in CART Cells and Uses Thereof

5/1/2025	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Publication Publication Publication Patent	18468043 16943335 15516240 20200407728 20170335331 20240279665 12344843	Altering Gene Expression in CART Cells and Uses Thereof Altering Gene Expression in CART Cells and Uses Thereof Altering Gene Expression in CART Cells and Uses Thereof Altering Gene Expression in CART Cells and Uses Thereof Altering Gene Expression in CART Cells and Uses Thereof Altering Gene Expression in CART Cells and Uses Thereof Altering Gene Expression in CART Cells and Uses Thereof

4/9/2025	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Publication Publication Publication Patent Patent	16148067 18048233 14044569 20140099309 20190125797 20230181643 10117896 11484552	Use of a Trans-Signaling Approach in Chimeric Antigen Receptors Use Of Trans-signaling Approach In Chimeric Antigen Receptors Use Of Trans-signaling Approach In Chimeric Antigen Receptors Use of a Trans-Signaling Approach in Chimeric Antigen Receptors Use Of Trans-signaling Approach In Chimeric Antigen Receptors Use of a Trans-Signaling Approach in Chimeric Antigen Receptors Use Of Trans-signaling Approach In Chimeric Antigen Receptors Use Of Trans-signaling Approach In Chimeric Antigen Receptors

4/9/2025	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Publication Publication Publication Patent Patent Patent	16148067 14044569 18048233 20190125797 20140099309 20230181643 11484552 10117896 12325756	Use Of Trans-signaling Approach In Chimeric Antigen Receptors Use of a Trans-Signaling Approach in Chimeric Antigen Receptors Use Of Trans-signaling Approach In Chimeric Antigen Receptors Use Of Trans-signaling Approach In Chimeric Antigen Receptors Use of a Trans-Signaling Approach in Chimeric Antigen Receptors Use Of Trans-signaling Approach In Chimeric Antigen Receptors Use Of Trans-signaling Approach In Chimeric Antigen Receptors Use of a Trans-Signaling Approach in Chimeric Antigen Receptors Use Of Trans-signaling Approach In Chimeric Antigen Receptors

4/1/2025	The Trustees Of The University Of Pennsy...	Assignee	Application Application Publication Publication Patent	12999926 17133702 20110268752 20210275650 9228172	Inducible Regulatory T-cell Generation For Hematopoietic Transplants Inducible Regulatory T-Cell Generation for Hematopoietic Transplants Inducible Regulatory T-cell Generation For Hematopoietic Transplants Inducible Regulatory T-Cell Generation for Hematopoietic Transplants Inducible Regulatory T-cell Generation For Hematopoietic Transplants

4/1/2025	The Trustees Of The University Of Pennsy...	Assignee	Application Application Application Publication Publication Publication Patent	19096073 12999926 17133702 20110268752 20210275650 20250288655 9228172	Inducible Regulatory T-cell Generation For Hematopoietic Transplants Inducible Regulatory T-cell Generation For Hematopoietic Transplants Inducible Regulatory T-Cell Generation for Hematopoietic Transplants Inducible Regulatory T-cell Generation For Hematopoietic Transplants Inducible Regulatory T-Cell Generation for Hematopoietic Transplants

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